Description

n-Nitroso-Prolyl-4-Hydroxyproline is a specialized nitrosated dipeptide derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical intermediate and reference standard for studying nitrosation processes, protein modifications, and related metabolic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on advanced peptide chemistry and biomarker analysis.

Application

• Biochemical Research: Used as a reference standard and intermediate in studies of nitrosated amino acids and peptides.
• Pharmaceutical Development: Serves as a key building block or analytical standard in the synthesis and analysis of novel therapeutic agents targeting nitrosative stress.
• Analytical Chemistry: Employed as a high-purity calibrant in HPLC, LC-MS, and other chromatographic methods for the detection and quantification of nitrosoproline derivatives.
• Metabolic Pathway Studies: Utilized in research investigating endogenous nitrosation, collagen metabolism, and the role of nitrosated proline derivatives as potential biomarkers.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the preparation of more complex nitrosated peptide structures and probes.
• Toxicology & Safety Assessment: Applied in studies assessing the formation and biological impact of N-nitroso compounds (NOCs) in various systems.

Basic Information

Item	Details
Product Name	n-Nitroso-Prolyl-4-Hydroxyproline
CAS No.	88476-96-4
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	N-Nitroso-L-prolyl-4-hydroxy-L-proline; L-Proline, N-nitroso-, 4-hydroxy-L-prolyl ester; Nitrosoprolylhydroxyproline; N-Nitroso-Pro-Hyp; (4R)-1-[(2S)-1-Nitroso-5-oxopyrrolidin-2-yl]-4-hydroxypyrrolidine-2-carboxylic acid; N-Nitroso-Prolyl-4(R)-Hydroxyproline; N-Nitroso-Pro-Hyp-OH
EINECS	Contact for details

Quality Control

Our n-Nitroso-Prolyl-4-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.