Description

1-Ethynyl-2,4-Bis((Trifluoromethyl))-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the ethynyl group combined with the strong electron-withdrawing effect of the trifluoromethyl substituents, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 groups can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, coatings, and liquid crystals with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create sophisticated ligands for catalysis, leveraging the alkyne functionality for coordination or further functionalization.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new C-C and C-F bond-forming reactions and the properties of highly fluorinated arenes.

Basic Information

Product Name	1-Ethynyl-2,4-Bis((Trifluoromethyl))-Benzene
CAS No.	88444-79-5
Molecular Formula	C10H4F6
Molecular Weight	238.13 g/mol
Synonyms	2,4-Bis(trifluoromethyl)phenylacetylene; 1-Ethynyl-2,4-bis(trifluoromethyl)benzene; 2,4-Bis(trifluoromethyl)ethynylbenzene; α-(2,4-Bis(trifluoromethyl)phenyl)acetylene; (2,4-Bis(trifluoromethyl)phenyl)ethyne
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2,4-Bis((Trifluoromethyl))-Benzene is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.