Description

Dehydro Nifedipine n-Oxide is a key pharmaceutical intermediate and a derivative of the calcium channel blocker nifedipine. This compound is primarily valued for its role in the research and development of cardiovascular drugs and in metabolic studies. It is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on synthesizing novel active pharmaceutical ingredients (APIs) or studying drug metabolism pathways.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of nifedipine analogs and related cardiovascular active pharmaceutical ingredients (APIs).
• Metabolite Reference Standard: Used as a certified reference material in analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies.
• Research & Development: Serves as a building block in medicinal chemistry for developing new calcium channel modulators.
• Quality Control: Employed as an impurity standard in the HPLC analysis of nifedipine and its finished pharmaceutical products to ensure purity and compliance.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical research projects.

Basic Information

Product Name	Dehydro Nifedipine n-Oxide
CAS No.	88434-69-9
Molecular Formula	C17H14N2O6
Molecular Weight	342.31 g/mol
Synonyms	Dehydronifedipine N-Oxide; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester 1-Oxide; Nifedipine Impurity F (EP); Nifedipine N-Oxide Dehydro Derivative; 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid Dimethyl Ester 1-Oxide; Nifedipine Related Compound F
EINECS	Contact for details

Quality Control

Our Dehydro Nifedipine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, to ensure it meets high-grade standards suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.