Description

n-Phenylsulfonyl-L-Proline is a chiral, non-proteinogenic amino acid derivative featuring a phenylsulfonyl protecting group on the proline nitrogen. This compound matters as a versatile and high-purity chiral building block, essential for the synthesis of complex pharmaceutical intermediates and bioactive peptides. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions due to its rigid, stereodefined structure.
• Biochemical Research: Employed in studying enzyme-substrate interactions, particularly with proline-specific enzymes like prolyl oligopeptidase.
• Chemical Biology Probes: Utilized in the development of activity-based probes and inhibitors targeting sulfonamide-binding proteins.
• Fine Chemical Synthesis: A building block for creating specialized compounds in agrochemical and material science research.

Basic Information

Product Name	n-Phenylsulfonyl-L-Proline
CAS No.	88425-47-2
Molecular Formula	C11H13NO4S
Molecular Weight	255.29 g/mol
Synonyms	L-Proline, N-[(phenylsulfonyl)-]; (S)-1-(Phenylsulfonyl)pyrrolidine-2-carboxylic Acid; N-(Phenylsulfonyl)-L-proline; 1-(Benzenesulfonyl)-L-proline; N-Benzenesulfonyl-L-proline; (S)-N-(Phenylsulfonyl)proline; NSC 334365; L-Phenylsulfonylproline
EINECS	Contact for details

Quality Control

Our n-Phenylsulfonyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.