Description

Disodium Clodronate Tetrahydrate is a high-purity bisphosphonate compound, recognized for its potent biological activity. This material is critical for applications requiring precise control of bone metabolism and calcium regulation. It is primarily utilized by the pharmaceutical and life science research sectors for the development of therapeutic agents and advanced experimental models.

Application

• Pharmaceutical Active Ingredient (API): Core component in medications for osteoporosis, Paget's disease, and bone metastases.
• Biomedical Research: Key reagent in studies of osteoclast biology, bone resorption, and macrophage depletion protocols.
• Veterinary Medicine: Used in treatments for skeletal disorders in companion and livestock animals.
• Reference Standard: Serves as a certified standard for quality control and analytical method development in laboratories.
• Formulation Development: Employed in the R&D of injectable solutions, oral tablets, and other drug delivery systems.

Basic Information

Product Name	Disodium Clodronate Tetrahydrate
CAS No.	88416-50-6
Molecular Formula	C2H4Cl2Na2O6P2 · 4H2O
Molecular Weight	360.90 g/mol (Anhydrous basis: 288.86)
Synonyms	Clodronate Disodium Tetrahydrate; Dichloromethylene Bisphosphonate Disodium Salt Tetrahydrate; Disodium Dichloromethylene Diphosphonate Tetrahydrate; Clodronic Acid Disodium Salt Tetrahydrate; BM-06011; MDP; Lytos
EINECS	Contact for details

Quality Control

Our Disodium Clodronate Tetrahydrate is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical development and research use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	17.0% - 22.0%
pH (5% Solution)	4.5 - 6.0
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.