Description

trans-Hydroxy Loxoprofen is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) Loxoprofen. This compound matters for its role in the synthesis and metabolic study of potent anti-inflammatory and analgesic agents. It is primarily needed by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and analytical reference standard suppliers for drug development and quality control processes.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Loxoprofen sodium and related NSAID APIs.
• Metabolite Reference Standard: Used in pharmacokinetic and drug metabolism studies to identify and quantify the active metabolite in biological matrices.
• Analytical Research: Serves as a high-purity standard for HPLC, LC-MS, and other chromatographic methods in pharmaceutical analysis.
• Process Development & Optimization: Employed in scaling up and refining synthetic routes for Loxoprofen production.
• Impurity Profiling: Used to identify, characterize, and control related substances in final drug product batches.
• Preclinical & Clinical Research: Supports investigative studies on the efficacy, safety, and mechanism of action of Loxoprofen.

Basic Information

Product Name	trans-Hydroxy Loxoprofen
CAS No.	88378-21-6
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	trans-2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propanoic Acid; (2RS)-2-[4-[(1RS,2SR)-2-Hydroxycyclopentyl]methyl]phenyl]propanoic Acid; Loxoprofen Alcohol Metabolite; Loxoprofen Trans-OH; Loxoprofen Metabolite I; (±)-trans-2-[4-[(2-Hydroxycyclopentyl)methyl]phenyl]propionic Acid; trans-Hydroxy Loxoprofen Sodium Salt (for salt forms)
EINECS	Contact for details

Quality Control

Our trans-Hydroxy Loxoprofen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.