Description

trans-3-Hydroxycyclobutanecarbonitrile is a versatile chiral building block featuring both a hydroxyl and a nitrile functional group on a cyclobutane ring. This unique structure makes it a valuable intermediate for the synthesis of complex pharmaceutical compounds and advanced materials. It is particularly sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures with specific stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Building block for polymers and liquid crystals where the rigid cyclobutane core and functional groups impart specific physical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, stereochemically defined intermediates.

Basic Information

Product Name	trans-3-Hydroxycyclobutanecarbonitrile
CAS No.	88315-80-4
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(1r,3r)-3-Hydroxycyclobutanecarbonitrile; trans-3-Hydroxycyclobutanecarbonitrile; (1R,3R)-3-Hydroxycyclobutanecarbonitrile; 3-Hydroxycyclobutanecarbonitrile; Cyclobutanecarbonitrile, 3-hydroxy-, trans-; 3-Cyano-1-hydroxycyclobutane; trans-3-Cyanocyclobutanol
EINECS	Contact for details

Quality Control

Our trans-3-Hydroxycyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged use to maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.