Description

cis-3-Hydroxycyclobutanecarbonitrile is a versatile chiral building block featuring both a nitrile and a hydroxyl functional group on a cyclobutane ring. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research. It is particularly sought after by R&D chemists and process development scientists for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific stereochemistry.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where the rigid cyclobutane scaffold is advantageous.
• Material Science Research: A building block for novel polymers and advanced materials with tailored properties.

Basic Information

Product Name	cis-3-Hydroxycyclobutanecarbonitrile
CAS No.	88315-79-1
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(1r,3s)-3-Hydroxycyclobutanecarbonitrile; (1R,3S)-3-Hydroxycyclobutanecarbonitrile; cis-3-Hydroxycyclobutanenitrile; 3-Hydroxycyclobutanecarbonitrile, cis-; 3-Cyano-1-hydroxycyclobutane; Cyclobutanecarbonitrile, 3-hydroxy-, cis-; (1R,3S)-3-Cyanocyclobutanol
EINECS	Contact for details

Quality Control

Our cis-3-Hydroxycyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.