Description

1-Chloro-1,1-Difluoroacetone is a versatile fluorinated building block and a key intermediate in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine atoms on the carbonyl, makes it a valuable reagent for introducing difluoromethyl and other fluorinated motifs into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty fluoropolymers with unique surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to construct complex, fluorinated organic frameworks.
• Liquid Crystal & Electronic Chemicals: A potential precursor for fluorine-containing compounds used in electronic materials and display technologies.

Basic Information

Product Name	1-Chloro-1,1-Difluoroacetone
CAS No.	88257-33-4
Molecular Formula	C3H3ClF2O
Molecular Weight	128.51 g/mol
Synonyms	Chlorodifluoroacetone; 1-Chloro-1,1-difluoro-2-propanone; 1,1-Difluoro-1-chloroacetone; 2-Propanone, 1-chloro-1,1-difluoro-; Acetone, 1-chloro-1,1-difluoro-; Monochlorodifluoroacetone
EINECS	Contact for details

Quality Control

Our 1-Chloro-1,1-Difluoroacetone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.