Description

H-Phe-Obzl p-Tosylate is a protected amino acid derivative, specifically the p-toluenesulfonate salt of benzyl L-phenylalaninate. This compound is a crucial chiral building block and intermediate in the synthesis of complex peptides and pharmaceutical active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new therapeutic agents and advanced materials. Its protected carboxyl group offers strategic advantages in multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected phenylalanine derivative.
• Research & Development: Serves as a standard or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Bioconjugation: Potential use in the preparation of peptide conjugates for diagnostic or targeted drug delivery systems.
• Chemical Biology: Employed in the synthesis of modified peptides for probing biological function and protein-protein interactions.
• Catalyst Ligand Preparation: Can be used to synthesize chiral ligands for asymmetric catalysis.

Basic Information

Product Name	H-Phe-Obzl p-Tosylate
CAS No.	88224-00-4
Molecular Formula	C23H25NO5S
Molecular Weight	427.51 g/mol
Synonyms	Benzyl L-phenylalaninate p-toluenesulfonate salt; L-Phenylalanine, benzyl ester, 4-methylbenzenesulfonate; H-Phe-OBzl.TosOH; (S)-Benzyl 2-amino-3-phenylpropanoate 4-methylbenzenesulfonate; Fmoc-Phe-OBzl precursor; Boc-Phe-OBzl Tosylate salt; Benzyl (S)-2-amino-3-phenylpropanoate tosylate; Protected Phenylalanine benzyl ester tosylate
EINECS	Contact for details

Quality Control

Our H-Phe-Obzl p-Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) providing detailed results for chiral purity, assay, and related substances are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.