Description

L-Alanine-2-D1-n-T-Boc CAS NO 88181-11-7 is a deuterium-labeled, Boc-protected derivative of the essential amino acid L-alanine, serving as a critical building block in advanced organic synthesis. This isotopically labeled compound is indispensable for mechanistic studies, metabolic pathway tracing, and the development of novel pharmaceuticals, where precise molecular tracking is required. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics, and the synthesis of complex peptides and labeled bioactive molecules.

Application

• Pharmaceutical Research & Drug Discovery: As a stable isotope-labeled intermediate for synthesizing deuterated drug candidates to study Absorption, Distribution, Metabolism, and Excretion (ADME).
• Proteomics & Metabolic Studies: Used in mass spectrometry as an internal standard for the accurate quantification of amino acids and peptides.
• Advanced Peptide Synthesis: A key protected monomer for the solid-phase and solution-phase synthesis of isotopically labeled peptides and proteins.
• Mechanistic Biochemistry: Employed in enzymatic and binding studies to elucidate reaction mechanisms and kinetics using isotope effects.
• NMR Spectroscopy: Acts as a useful probe in Nuclear Magnetic Resonance (NMR) spectroscopy due to the deuterium label, simplifying spectral analysis.
• Production of Labeled Fine Chemicals: Serves as a precursor for manufacturing other deuterated fine chemicals and specialty biochemicals.

Basic Information

Product Name	L-Alanine-2-D1-n-T-Boc
CAS No.	88181-11-7
Molecular Formula	C8H14DNO4
Molecular Weight	190.22 g/mol (for monoisotopic mass)
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]propanoic-2-d acid; Boc-L-alanine-2-d; N-(tert-Butoxycarbonyl)-L-alanine-2-d1; tert-Butyl (2S)-2-carboxy-1-(2H)propylcarbamate; Deuterated Boc-L-alanine; L-2-Aminopropionic-2-d acid N-Boc derivative; Boc-Ala-2-d-OH; BOC-L-Alanine-d1
EINECS	Contact for details

Quality Control

Our L-Alanine-2-D1-n-T-Boc is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR or MS), chiral purity, and moisture content. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	[α]²⁰D = Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.