Description

Platelet Factor 4 (59-70) is a specific bioactive peptide fragment derived from the native Platelet Factor 4 protein. This compound is a critical research tool for studying platelet biology, thrombosis, and inflammation pathways. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, assay development, and biochemical research. The product is supplied with a high level of purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Biochemical Research: Used as a standard or reagent in studies investigating the role of PF4 in hemostasis, thrombosis, and angiogenesis.
• Assay Development: Serves as a critical component in the development of immunoassays (e.g., ELISA) to detect PF4 or PF4-antibody complexes.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify novel inhibitors or modulators of PF4 activity for therapeutic applications.
• Heparin-Induced Thrombocytopenia (HIT) Studies: Essential for in vitro research models of HIT, a serious immune-mediated complication of heparin therapy.
• Cell Signaling & Inflammatory Response Studies: Used to stimulate cells and study downstream signaling cascades related to inflammation and immune response.
• Peptide Chemistry & Conjugation: Acts as a substrate or building block for peptide synthesis, modification, or conjugation projects.

Basic Information

Product Name	Platelet Factor 4 (59-70)
CAS No.	88145-47-5
Molecular Formula	C58H94N20O19S2
Molecular Weight	1439.6 g/mol
Synonyms	PF4 (59-70); Platelet Factor 4 Fragment (59-70); PF4 Peptide (59-70); LDMLLQEVGSKSP; H-PF4 (59-70); CXCL4 (59-70); Chemokine (C-X-C motif) ligand 4 (59-70); Thrombocytin fragment
EINECS	Contact for details

Quality Control

Our Platelet Factor 4 (59-70) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Sequence	LDMLLQEVGSKSP (Single-Letter: L-D-M-L-L-Q-E-V-G-S-K-S-P)
Molecular Weight	1439.6 ± 1.0 Da
Water Content (K.F.)	≤ 5.0%
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.