Description

γ-(4-Aminophenyl) 7-Methylguanosine 5'-Triphosphate is a chemically modified nucleotide triphosphate analog designed for advanced biochemical research and diagnostic applications. This compound is critical for applications requiring the stable incorporation of a primary amine functional group into nucleic acid polymers, enabling subsequent labeling and conjugation. It is primarily utilized by researchers and developers in the fields of molecular biology, next-generation sequencing (NGS), and diagnostic assay development.

Application

• Next-Generation Sequencing (NGS): Used as a modified nucleotide for sequencing-by-synthesis platforms to introduce specific chemical handles.
• Nucleic Acid Labeling and Detection: The 4-aminophenyl moiety serves as a conjugation site for attaching fluorophores, biotin, or other reporter molecules via amine-reactive chemistry.
• Probe Synthesis: Essential for creating highly sensitive and specific labeled probes for FISH (Fluorescence In Situ Hybridization), microarrays, and other hybridization assays.
• Enzymatic Studies: Acts as a substrate analog to study the kinetics and specificity of DNA/RNA polymerases and other nucleotide-processing enzymes.
• Diagnostic Kit Manufacturing: A key raw material in the production of kits for pathogen detection, genetic testing, and companion diagnostics.
• Aptamer and SELEX Technology: Facilitates the development of modified aptamers with enhanced stability and functionality for therapeutic and sensing applications.

Basic Information

Item	Detail
Product Name	γ-(4-Aminophenyl) 7-Methylguanosine 5'-Triphosphate
CAS No.	88106-70-1
Molecular Formula	C22H28N8O15P3
Molecular Weight	737.43 g/mol
Synonyms	7-Methylguanosine-5'-triphosphate, γ-(4-aminophenyl) ester; 4-Aminophenyl-7-methyl-GTP; γ-(4-Aminophenyl)-7-methyl-GTP; N7-Methylguanosine-5'-triphosphate γ-(4-aminophenyl) ester; GTP, 7-methyl-, γ-(4-aminophenyl) ester; Modified Nucleotide Triphosphate; Amino-functionalized GTP analog; 7-Me-GTP-γ-ANP
EINECS	Contact for details

Quality Control

Every batch of γ-(4-Aminophenyl) 7-Methylguanosine 5'-Triphosphate is manufactured and tested under stringent quality systems. We ensure high purity and consistency suitable for sensitive research and in-vitro diagnostic (IVD) applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity (HPLC), identity (NMR, MS), and absence of contaminating nucleases. Our quality commitment aligns with the standards expected for molecular biology grade reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.