Description

Methyl(R)-3-(Dibenzylamino)-2-Fluoropropanoate CAS NO 88099-68-7 is a high-value, chiral fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in the precise stereochemistry and the presence of both fluorine and protected amine functionalities, enabling the construction of complex molecules with targeted biological activity. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs focused on protease inhibitors and other enzyme-targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorine atom and stereogenic center, which can modulate potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, where the fluorine moiety often enhances biological activity and environmental persistence.
• Peptidomimetic Research: Employed in the design and synthesis of peptide mimics, where the dibenzylamino group acts as a protected amine handle and the fluorine influences conformation.
• Asymmetric Synthesis: Utilized as a substrate or reagent in catalytic asymmetric transformations to create other enantiomerically enriched compounds.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Methyl(R)-3-(Dibenzylamino)-2-Fluoropropanoate
CAS No.	88099-68-7
Molecular Formula	C18H20FNO2
Molecular Weight	301.36 g/mol
Synonyms	(R)-Methyl 3-(Dibenzylamino)-2-fluoropropanoate; Methyl (R)-3-(Dibenzylamino)-2-fluoropropionate; (R)-2-Fluoro-3-(dibenzylamino)propanoic acid methyl ester; 2-Fluoro-3-(dibenzylamino)propanoic acid methyl ester, (R)-; Methyl (3R)-3-(dibenzylamino)-2-fluoropropanoate; Methyl 3-(dibenzylamino)-2-fluoropropanoate, (R)-; DBFMP; (R)-DBFMP
EINECS	Contact for details

Quality Control

Our Methyl(R)-3-(Dibenzylamino)-2-Fluoropropanoate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this moisture-sensitive compound from atmospheric humidity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.