Description

Potassium (2S-Trans)-3-[[[2-(Formylamino)Thiazol-4-Yl]Oxoacetyl]Amino]-2-Methyl-4-Oxoazetidine-1-Sulphonate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key building block in the synthesis of modern β-lactam antibiotics, particularly certain cephalosporins, where its specific stereochemistry is critical for biological activity. It is essential for manufacturers and research institutions in the pharmaceutical and fine chemical sectors focused on developing and producing next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced cephalosporin-class antibiotics.
• Antibacterial API Synthesis: Used in the research and commercial production of active pharmaceutical ingredients (APIs) targeting resistant bacterial strains.
• Fine Chemical Research: Serves as a specialized reagent in medicinal chemistry for the design and development of novel β-lactam structures.
• Process Chemistry: Employed in scale-up and optimization studies for the industrial manufacturing of antibiotic drugs.
• Biochemical Studies: Utilized in research to study the structure-activity relationships (SAR) and mechanism of action of β-lactam compounds.

Basic Information

Item	Details
Product Name	Potassium (2S-Trans)-3-[[[2-(Formylamino)Thiazol-4-Yl]Oxoacetyl]Amino]-2-Methyl-4-Oxoazetidine-1-Sulphonate
CAS No.	88023-65-8
Molecular Formula	C11H11KN4O7S2
Molecular Weight	414.45 g/mol
Synonyms	Potassium (2S-trans)-3-[[2-(Formylamino)-4-thiazolylacetyl]amino]-2-methyl-4-oxo-1-azetidinesulfonate; 7β-[2-(2-Aminothiazol-4-yl)-2-(formyloxyimino)acetamido]-3-cephem-4-carboxylic Acid Potassium Salt Derivative; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Related Compound; Potassium 7β-[2-(2-Formamidothiazol-4-yl)-2-(methoxyimino)acetamido]-3-methyl-3-cephem-4-carboxylate 1,1-Dioxide; Cephalosporin C-7 Side Chain Potassium Salt; β-Lactam Intermediate Potassium Salt; ATKA Potassium Salt; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Potassium (2S-Trans)-3-[[[2-(Formylamino)Thiazol-4-Yl]Oxoacetyl]Amino]-2-Methyl-4-Oxoazetidine-1-Sulphonate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2S-trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.