Description

2-(4-Fluorobenzyl)Acetoacetic Acid Ethyl Ester is a versatile fluorinated organic building block of significant importance in advanced chemical synthesis. Its molecular structure, featuring both an acetoacetate ester and a fluorinated benzyl group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including potential central nervous system (CNS) agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Organic Synthesis Building Block: Serves as a versatile reagent for Knoevenagel condensations, Michael additions, and other reactions to create complex molecular architectures.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic or optical properties.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in route scouting and optimization for new chemical entities.

Basic Information

Product Name	2-(4-Fluorobenzyl)Acetoacetic Acid Ethyl Ester
CAS No.	88023-07-8
Molecular Formula	C13H15FO3
Molecular Weight	238.26 g/mol
Synonyms	Ethyl 2-(4-Fluorobenzyl)-3-oxobutanoate; Ethyl (4-Fluorobenzyl)acetoacetate; 3-Oxobutanoic acid, 2-[(4-fluorophenyl)methyl]-, ethyl ester; Acetoacetic acid, (p-fluorobenzyl)-, ethyl ester; 2-(4-Fluorobenzyl)-3-oxobutyric acid ethyl ester; Ethyl 2-(4-fluorobenzyl)acetoacetate; 88023-07-8
EINECS	Contact for details

Quality Control

Our production of 2-(4-Fluorobenzyl)Acetoacetic Acid Ethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (typically >97% by HPLC), identity confirmation, and impurity profiles. We are committed to meeting the exacting requirements of GMP-aligned production for pharmaceutical intermediates and support regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.