Description

Angiotensin II, Cys(1,8)- is a synthetic, cyclic analog of the endogenous vasoconstrictor peptide Angiotensin II, specifically modified with cysteine residues at positions 1 and 8 to form a disulfide bridge. This structural modification confers enhanced stability and specific receptor-binding properties, making it a critical tool for cardiovascular and endocrine research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers investigating the renin-angiotensin system (RAS), hypertension, and related metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS), vascular biology, and blood pressure regulation.
• Pharmacological Assay Development: Serves as a key ligand in receptor binding assays (AT1 and AT2 receptors) and functional studies for screening potential antihypertensive drugs.
• Diagnostic Reagent Manufacturing: Employed in the production of immunoassay kits, such as ELISA, for the quantitative measurement of angiotensin-related biomarkers.
• Peptide Chemistry & Structure-Activity Relationship (SAR) Studies: Acts as a model compound for studying the impact of disulfide bond formation on peptide conformation, stability, and biological activity.
• Cell Signaling & Physiology Studies: Applied in cellular models to investigate angiotensin-mediated signal transduction pathways, including those involved in hypertrophy, fibrosis, and inflammation.

Basic Information

Product Name	Angiotensin II, Cys(1,8)-
CAS No.	87937-69-7
Molecular Formula	C49H69N13O12S2
Molecular Weight	1088.3 g/mol
Synonyms	[Cys1, Cys8]-Angiotensin II; Cyclo(1,8)-Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Cys (cyclic 1-8 disulfide); H-Asp-Arg-Val-Tyr-Ile-His-Pro-Cys-OH (1-8 disulfide); Angiotensin II (1-8) cyclic disulfide; c[Asp1,Cys8]Ang II; ATII cyclic analog
EINECS	Contact for details

Quality Control

Our Angiotensin II, Cys(1,8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity requirements (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.