Description

Complement C4B Binding Protein is a highly purified regulatory protein that plays a critical role in the classical and lectin pathways of the complement system. Its primary function is to act as a cofactor for Factor I in the cleavage and inactivation of C4b, thereby controlling complement activation and preventing excessive immune response. This protein is essential for research and development in immunology, diagnostics, and biopharmaceuticals, particularly for studying autoimmune diseases, inflammatory disorders, and developing therapeutic inhibitors.

Application

• Immunological Research: Fundamental studies on the regulation of the complement cascade and immune system modulation.
• Diagnostic Reagent Production: A key component in ELISA kits, lateral flow assays, and other in vitro diagnostic (IVD) tools for detecting complement pathway activity.
• Biopharmaceutical Development: Used as a reference standard, target antigen, or raw material in the development of monoclonal antibodies, protein-based therapeutics, and complement-targeting drugs.
• Autoimmune Disease Studies: Investigation into pathologies like systemic lupus erythematosus (SLE), rheumatoid arthritis, and atypical hemolytic uremic syndrome (aHUS) where complement dysregulation is implicated.
• Quality Control & Assay Standards: Serves as a calibrated standard in bioassays to ensure the consistency and potency of related biological products.
• Academic & Clinical Research: Utilized in university and hospital laboratories for both basic science and translational clinical research projects.

Basic Information

Product Name	Complement C4B Binding Protein
CAS No.	87843-67-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	C4BP; C4b-Binding Protein; Complement Component 4 Binding Protein; C4b-BP; Complement C4b-Binding Protein, Alpha Chain; C4BPA; Proline-rich protein
EINECS	Contact for details

Quality Control

Our Complement C4B Binding Protein is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by SDS-PAGE and HPLC, functional activity assays, and endotoxin level verification. Certificates of Analysis (COA) detailing purity, concentration, biological activity, and sterility (where applicable) are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	> 95%
Identification (Western Blot)	Positive for C4BP
Protein Concentration	As per COA (typically 0.5 - 1.0 mg/mL)
Biological Activity (Cofactor Assay)	Functional
Endotoxin Level	< 1.0 EU/μg (for in vitro use)
Solubility	Soluble in PBS or Tris-based buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.