Description

1,25-Dihydroxyvitamin D3-23,26-Lactol is a key synthetic intermediate in the production of biologically active vitamin D analogs and related compounds. This compound is of significant value for pharmaceutical research and development, particularly in the synthesis of calcitriol derivatives and other secosteroids with targeted therapeutic effects. It is primarily required by fine chemical manufacturers, pharmaceutical R&D laboratories, and academic institutions engaged in endocrinology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of active vitamin D metabolites and their analogs, such as calcitriol (1,25-dihydroxyvitamin D3).
• Research & Development: Used in academic and industrial labs to study structure-activity relationships (SAR) of vitamin D receptor (VDR) ligands.
• Fine Chemical Synthesis: Serves as a building block for creating novel secosteroids with potential applications in treating osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Tool Compound: Employed in metabolic pathway studies to understand the biosynthesis and catabolism of vitamin D.
• Reference Standard: Can be utilized as a chromatographic reference standard in analytical method development for vitamin D analog purity testing.

Basic Information

Product Name	1,25-Dihydroxyvitamin D3-23,26-Lactol
CAS No.	87680-15-7
Molecular Formula	C27H42O4
Molecular Weight	430.62 g/mol
Synonyms	1,25-Dihydroxycholecalciferol-23,26-Lactol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,23,25-tetrol, 23,26-Lactol; 1α,25-Dihydroxyvitamin D3-23,26-Lactol; Calcitriol Lactol Intermediate; Vitamin D3 Lactol Derivative; 23,26-Lactol of 1,25-Dihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxyvitamin D3-23,26-Lactol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR), to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.