Description

Tetrahydrosepiapterin is a reduced form of sepiapterin and a key intermediate in the biosynthesis of the essential cofactor tetrahydrobiopterin (BH4). This compound is critical for research and development in biochemistry and pharmaceutical sciences, particularly in studies related to nitric oxide synthases, aromatic amino acid hydroxylases, and neurotransmitter synthesis. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies developing therapies for metabolic and neurological disorders linked to BH4 deficiency.

Application

• Biochemical Research: Essential substrate and reference standard in enzymatic studies of phenylalanine, tyrosine, and tryptophan hydroxylases.
• Pharmaceutical Development: Key intermediate in the synthesis pathway for therapeutic agents targeting conditions like phenylketonuria (PKU) and dopamine-responsive dystonia.
• Diagnostic Reagents: Used in the formulation of assay kits for the detection and quantification of biopterin and related metabolites in clinical samples.
• Cell Culture & Neuroscience: Employed in cell-based studies to investigate the role of tetrahydrobiopterin in neuroprotection, neurotransmitter regulation, and endothelial function.
• Enzyme Cofactor Studies: Serves as a precursor in research on nitric oxide synthase (NOS) activity and its implications for cardiovascular and immune system function.

Basic Information

Product Name	Tetrahydrosepiapterin
CAS No.	87622-51-3
Molecular Formula	C9H15N5O3
Molecular Weight	241.25 g/mol
Synonyms	6-(L-erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydropterin; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one; THSP; Tetrahydro-sepiapterin; 5,6,7,8-Tetrahydrosepiapterin
EINECS	Contact for details

Quality Control

Our Tetrahydrosepiapterin is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.