Description

Penicillinaseexbacilluscereus569/H9 is a highly purified enzyme preparation derived from a specific strain of *Bacillus cereus*. This product is critical for the selective inactivation of penicillin antibiotics, serving as an essential tool in pharmaceutical quality control and microbiological research. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions requiring precise and reliable penicillin degradation for sterility testing, antibiotic residue analysis, and method development.

Application

• Pharmaceutical Sterility Testing: Used in the BacT/ALERT® and BACTEC® systems and other sterility test methods to neutralize penicillin antibiotics in samples, allowing for the accurate detection of microbial contamination.
• Antibiotic Residue Analysis: Employed in sample preparation for HPLC, LC-MS, or microbial inhibition assays to degrade penicillin residues in food, animal feed, and environmental samples.
• Microbiological Assay Development: Serves as a key reagent in developing and validating bioassays for antibiotic potency, ensuring specific measurement of non-penicillin components.
• Cell Culture and Fermentation: Used to inactivate penicillin in cell culture media or fermentation broths where the antibiotic was used for selection, enabling downstream processing.
• Diagnostic Kit Manufacturing: Incorporated into diagnostic kits and reagents designed for the detection of β-lactamase producing organisms or for specific antibiotic resistance testing.
• Research on Antibiotic Resistance: Applied in biochemical and microbiological research studies focusing on β-lactamase enzyme kinetics, mechanism of action, and resistance profiling.

Basic Information

Product Name	Penicillinaseexbacilluscereus569/H9
CAS No.	87608-74-0
Molecular Formula	N/A (Enzyme Preparation)
Molecular Weight	N/A (Enzyme Preparation)
Synonyms	Penicillinase from Bacillus cereus; β-lactamase (Bacillus cereus); Penase; Penicillin Inactivating Enzyme; Penicillinase Concentrate; B. cereus β-lactamase; Penicillinase 569/H9; ATCC 13061 Penicillinase
EINECS	Contact for details

Quality Control

Our Penicillinaseexbacilluscereus569/H9 is manufactured under strict quality management systems. Each batch is tested to ensure high specific activity, low endotoxin levels, and the absence of contaminating protease or nuclease activities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay results, purity, and stability data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, avoid repeated freeze-thaw cycles and store desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (IR)	Conforms to reference standard
Assay (Activity)	≥ [Value] units/mg protein
Protein Content (Biuret)	Reported on COA
Specific Activity	Reported on COA
Endotoxin (LAL)	< 10.0 EU/mg
pH (in solution)	6.0 - 8.0
Solubility	Completely soluble in water or specified buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.