Description

Methyl 2-Amino-3,3,3-Trifluoro-2-Methylpropanoate is a high-value, non-proteinogenic amino acid ester derivative characterized by its trifluoromethyl group, which imparts unique physicochemical properties. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for introducing fluorine-containing motifs. It is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to enhance the metabolic stability, bioavailability, and binding affinity of novel active ingredients. The precise control over its stereochemistry and purity is paramount for successful downstream applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other therapeutics where the trifluoromethyl group modulates biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging fluorine's ability to improve lipophilicity and environmental stability.
• Peptidomimetics & Bioactive Molecules: Incorporation into peptide analogs and other bioactive compounds to study structure-activity relationships and improve drug-like properties.
• Material Science Precursor: Acts as a specialty monomer or precursor for developing fluorinated polymers and advanced materials with specific surface characteristics.
• Asymmetric Synthesis: Employed as a substrate or auxiliary in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Chemical Biology Research: Utilized as a probe or labeled compound in metabolic pathway studies and mechanism-of-action research.

Basic Information

Product Name	Methyl 2-Amino-3,3,3-Trifluoro-2-Methylpropanoate
CAS No.	87492-64-6
Molecular Formula	C6H10F3NO2
Molecular Weight	185.14 g/mol
Synonyms	2-Amino-3,3,3-trifluoro-2-methylpropanoic acid methyl ester; Methyl 2-amino-3,3,3-trifluoro-2-methylpropionate; 3,3,3-Trifluoro-2-aminoisobutyric acid methyl ester; 2-Methyl-2-amino-3,3,3-trifluoropropionic acid methyl ester; Methyl α-amino-β,β,β-trifluoroisobutyrate; (RS)-Methyl 2-amino-3,3,3-trifluoro-2-methylpropanoate; Trifluoromethyl alanine methyl ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Amino-3,3,3-Trifluoro-2-Methylpropanoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), enantiomeric excess, and impurity profiles are provided with each shipment. We support compliance with relevant regulatory frameworks for pharmaceutical and agrochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.