Description

Biotinyl-Substance P CAS NO 87468-58-4 is a biotinylated derivative of the neuropeptide Substance P, designed for high-affinity detection and isolation applications. This modified peptide is a critical reagent in advanced biochemical research, enabling precise targeting and visualization of the neurokinin-1 (NK-1) receptor. It is primarily utilized by research scientists and pharmaceutical developers in neuroscience, immunology, and drug discovery for applications such as receptor binding studies, affinity purification, and cellular imaging.

Application

• Receptor Binding Assays & Competition Studies: Used as a labeled ligand to study the affinity, density, and kinetics of the NK-1 receptor.
• Affinity Chromatography & Purification: Immobilized on streptavidin/avidin resins for the selective isolation of receptor proteins or associated complexes.
• Immunohistochemistry & Cellular Imaging: Employed with fluorescent or enzymatic streptavidin conjugates to visualize receptor localization and distribution in tissues and cells.
• Biomarker Detection & Diagnostic Development: Serves as a key component in assay development for detecting Substance P pathways in inflammatory and neurological conditions.
• Signal Amplification Systems: Utilized in ELISA and other immunoassays to enhance detection sensitivity through the strong biotin-streptavidin interaction.
• High-Throughput Screening (HTS): Applied in pharmaceutical screening platforms to identify potential antagonists or modulators of the NK-1 receptor pathway.

Basic Information

Product Name	Biotinyl-Substance P
CAS No.	87468-58-4
Molecular Formula	C78H124N22O18S
Molecular Weight	1665.0 g/mol (approx.)
Synonyms	Biotin-Substance P; Biotinylated Substance P; Substance P, biotin conjugate; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (biotinyl); Biotin-SP; Biotinyl-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Neurokinin P, biotinylated; NK-1 Receptor Ligand, Biotin Labeled
EINECS	Contact for details

Quality Control

Every batch of Biotinyl-Substance P is manufactured and analyzed under strict quality protocols to ensure high purity, consistent biological activity, and reliable performance in sensitive research applications. Our quality system includes comprehensive analytical testing by HPLC and MS. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, peptide content, and identity, is supplied with each order and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.