Description

Haloperidol Hemisuccinate is a hemisuccinate ester salt of the potent butyrophenone antipsychotic agent, Haloperidol. This pharmaceutical intermediate is critical for the formulation of injectable and other dosage forms, offering enhanced solubility and stability profiles. It is primarily required by pharmaceutical manufacturers and research organizations engaged in the development and production of neuroleptic medications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key precursor in the synthesis of finished dosage forms of Haloperidol.
• Injectable Formulations: Utilized in the production of long-acting depot injections due to its esterified form, which can modify release kinetics.
• Pharmaceutical Research & Development: Serves as a critical reference standard and starting material in preclinical and clinical studies for antipsychotic drugs.
• Analytical Standard: Used in quality control laboratories for method development, validation, and assay calibration (HPLC, GC).
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for Haloperidol-based therapeutics.

Basic Information

Product Name	Haloperidol Hemisuccinate
CAS No.	87425-73-8
Molecular Formula	C25H32ClFNO6
Molecular Weight	505.98 g/mol
Synonyms	Haloperidol hydrogen succinate; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hemisuccinate; Haloperidol 21-hemisuccinate; Haloperidol succinate; Haldol hemisuccinate; R 1625 hemisuccinate
EINECS	Contact for details

Quality Control

Our Haloperidol Hemisuccinate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.