Description

Indomethacin-D4 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) indomethacin, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is an essential internal standard for accurate quantification in bioanalytical research, ensuring precision and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemistry facilities engaged in pharmacokinetic studies, drug metabolism research, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of indomethacin in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism and Metabolite Identification: Used in high-resolution mass spectrometry to differentiate drug-derived metabolites from endogenous compounds.
• Analytical Method Development and Validation: Essential for developing robust, sensitive, and specific HPLC or UPLC methods compliant with FDA and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for indomethacin active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Doping Control Analysis: Provides a reliable isotopic standard for confirmatory testing in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Indomethacin-D4
CAS No.	87377-08-0
Molecular Formula	C19H12D4ClNO4
Molecular Weight	361.81 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic-d4 acid; [2,4,5,6-D4]-Indomethacin; Indomethacin (phenyl-D4); Deuterated Indomethacin; Indomethacin-d4; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic-d4 acid; Indometacin-D4
EINECS	Contact for details

Quality Control

Our Indomethacin-D4 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR for deuterium incorporation and HPLC for chemical purity. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.