Description

(3,4-Dehydro-Pro2,4)-Substance P CAS NO 87367-30-4 is a synthetic, modified analog of the endogenous neuropeptide Substance P, designed for advanced biochemical and pharmacological research. This compound is of significant value for studying tachykinin receptor interactions, neuroinflammatory pathways, and pain signaling mechanisms due to its specific structural modifications. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, drug discovery, and peptide chemistry.

Application

• Neuroscience Research: A critical tool for investigating the role of Substance P and its receptors (NK1) in central and peripheral nervous system function.
• Pharmacological Studies: Used in receptor binding assays, functional activity tests, and signal transduction pathway analysis to screen and characterize new therapeutic candidates.
• Pain and Inflammation Models: Applied in preclinical research to model neurogenic inflammation and chronic pain conditions, helping to validate novel analgesic targets.
• Biochemical Standard: Serves as a high-purity reference standard for analytical method development, calibration, and quality control in peptide analysis.
• Drug Discovery & Development: Employed in structure-activity relationship (SAR) studies to design more stable or potent peptide-based therapeutics.

Basic Information

Product Name	(3,4-Dehydro-Pro2,4)-Substance P
CAS No.	87367-30-4
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.6 g/mol
Synonyms	[pGlu5, Dehydro-Pro2,4]-Substance P (5-11); Substance P (5-11), [pGlu5, δPro2,4]-; (3,4-Dehydro-Pro2,4)-SP; Modified Substance P analog; Tachykinin receptor ligand; Neurokinin-1 (NK1) receptor research peptide; Arg-Pro-Lys-Pro-[δPro]2-Gln-[δPro]4-Phe
EINECS	Contact for details

Quality Control

Our (3,4-Dehydro-Pro2,4)-Substance P is manufactured under strict quality management systems to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.