Description

Insulin, 3,5-Diiodo-Tyr(A19)- CAS NO 87347-15-7 is a chemically modified insulin derivative where the tyrosine residue at position A19 is specifically iodinated. This modification is critical for research into insulin's structure-activity relationships and receptor binding mechanisms. It serves as an essential biochemical tool for scientists in pharmaceutical R&D and academic institutions studying diabetes, peptide hormone signaling, and metabolic disorders.

Application

• Biochemical Research: Used as a key reagent in studies investigating the structure, function, and binding affinity of insulin to its receptor.
• Pharmaceutical Development: Acts as a reference standard or intermediate in the development of novel insulin analogs and diabetes therapeutics.
• Metabolic Studies: Employed in laboratory experiments to understand insulin signaling pathways and their role in glucose metabolism.
• Analytical Standard: Serves as a high-purity standard for analytical methods such as HPLC and mass spectrometry in quality control laboratories.
• Peptide Chemistry: Provides a model compound for studying iodination reactions and the effects of specific amino acid modifications on peptide stability and activity.

Basic Information

Product Name	Insulin, 3,5-Diiodo-Tyr(A19)- CAS NO 87347-15-7
CAS No.	87347-15-7
Molecular Formula	C257H387N65O77S6 (I2)
Molecular Weight	~5880 g/mol (monoisotopic)
Synonyms	3,5-Diiodotyrosine(A19)-Insulin; A19-Diiodoinsulin; Insulin iodinated at Tyr-A19; Monoiodoinsulin (A19); Diiodo-Tyr-A19-Insulin; [3,5-DiiodotyrosineA19]-Insulin; Insulin (3,5-Diiodo-L-tyrosineA19)
EINECS	Contact for details

Quality Control

Our Insulin, 3,5-Diiodo-Tyr(A19)- CAS NO 87347-15-7 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for research applications. A Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Biological Activity	To be determined by end-user assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.