Description

n-Acetyl-4,5-Dehydro-Dl-Leucine is a chemically modified, non-proteinogenic amino acid derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its unique dehydro-leucine structure makes it valuable for introducing specific steric and electronic properties into target molecules, enabling the development of novel compounds with tailored functionalities. This high-purity intermediate is essential for research and production in the pharmaceutical sector, particularly in medicinal chemistry for drug discovery and the synthesis of peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological targets.
• Peptidomimetics Research: Used to synthesize modified peptide analogs where the dehydro-leucine moiety can influence backbone conformation and biological activity.
• Bioconjugation & Probe Development: Serves as a building block for creating chemical probes and affinity labels used in biochemical and proteomic studies.
• Agrochemical Synthesis: Employed as an intermediate in the design of novel, biologically active compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and for exploring new reaction pathways in organic chemistry.

Basic Information

Product Name	n-Acetyl-4,5-Dehydro-Dl-Leucine
CAS No.	87325-65-3
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	N-Acetyl-4,5-dehydro-DL-leucine; 2-Acetamido-4-methylpent-4-enoic acid; Ac-DHLeu-OH; (RS)-2-Acetamido-4-methylpent-4-enoic acid; 4,5-Dehydro-N-acetyl-DL-leucine; DL-2-Acetylamino-4-methyl-4-pentenoic acid; N-Acetyl-dehydroleucine; N-Acetyl-4-methyl-4-pentenoic acid-2-amide
EINECS	Contact for details

Quality Control

Our n-Acetyl-4,5-Dehydro-Dl-Leucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.