Description

2-[[[(1Z)-1-(2-Amino-4-Thiazolyl)-2-[[(2R,3S)-2-Methyl-4-Oxo-1-Sulfo-3-Azetidinyl]Amino]-2-Oxoethylidene]Amino]Oxy]-2-Methylpropanoic Acid Dipotassium Salt is a high-purity, dipotassium salt derivative of a complex β-lactam structure, serving as a critical advanced pharmaceutical intermediate. Its primary value lies in enabling the synthesis of next-generation cephalosporin antibiotics, offering enhanced stability and bioavailability. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of potent antibacterial agents.

Application

• Key Intermediate in Cephalosporin Synthesis: Serves as a crucial building block for the production of advanced third and fourth-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for designing and testing novel β-lactam compounds with improved efficacy against resistant bacteria.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the controlled synthesis of final drug substances under current Good Manufacturing Practice (cGMP) conditions.
• Antibacterial Mechanism Studies: Utilized in biochemical research to study structure-activity relationships (SAR) and bacterial resistance mechanisms.
• Process Chemistry Optimization: Acts as a reference standard for scaling up and validating efficient synthetic routes in pilot plants.

Basic Information

Product Name	2-[[[(1Z)-1-(2-Amino-4-Thiazolyl)-2-[[(2R,3S)-2-Methyl-4-Oxo-1-Sulfo-3-Azetidinyl]Amino]-2-Oxoethylidene]Amino]Oxy]-2-Methylpropanoic Acid Dipotassium Salt
CAS No.	87291-17-6
Molecular Formula	C14H17KN5O9S2 (Contact for precise formula details)
Molecular Weight	Contact for details
Synonyms	Dipotassium (Z)-2-[[[1-(2-Amino-4-thiazolyl)-2-[[(2R,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoate; Cefotaxime Impurity; Cefotaxime Related Compound; β-Lactam Intermediate; 3-Azetidinesulfonic acid derivative; (2R,3S)-2-Methyl-4-oxo-1-sulfo-3-azetidinylamino oxyacetic acid dipotassium salt analog; Antibiotic synthesis intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and impurity profiling, spectroscopic identification (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your specifications. We support development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.