Description

Ethanone, 2,2,2-Trifluoro-1-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]- (9Ci) is a specialized, high-purity diazirine-based photoaffinity labeling reagent. This compound is critical for advanced biochemical research and pharmaceutical development, enabling the covalent cross-linking of biomolecules upon photoirradiation. It is primarily utilized by research scientists and process chemists in the fields of medicinal chemistry, proteomics, and chemical biology for mapping molecular interactions and drug target identification.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent tagging of proteins, nucleic acids, and other biological targets to study binding sites and interaction networks.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and target identification studies for novel drug candidates.
• Medicinal Chemistry: Employed in the synthesis and development of photolabile probes and covalent inhibitors for therapeutic agents.
• Chemical Biology Tool Development: Serves as a building block for creating advanced molecular probes to investigate biological pathways and mechanisms.
• Material Science Surface Modification: Potential use in creating photoresponsive surfaces and polymers via its reactive diazirine group.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]- (9Ci)
CAS No.	87282-23-3
Molecular Formula	C5H2F6N2O
Molecular Weight	220.08 g/mol
Synonyms	3-(Trifluoromethyl)-3-(3,3,3-trifluoropropanoyl)diazirine; 3,3,3-Trifluoro-1-[3-(trifluoromethyl)diazirin-3-yl]ethanone; 3-(Trifluoromethyl)-3H-diazirin-3-yl 2,2,2-trifluoroethyl ketone; TFDK-Ethone; Trifluoromethyl Diazirine Ketone; Photoaffinity Labeling Reagent 87282-23-3; Diazirinyl Trifluoromethyl Ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]- (9Ci) is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant industry standards for fine chemical production, and custom purity grades or analytical testing are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. Due to its highly volatile and strictly light-sensitive nature, this material must be handled under inert atmosphere (e.g., nitrogen or argon) when opening and aliquoting to prevent decomposition and ensure maximum shelf life. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.