Description

3-Cholesteryl 6-(n-Iminobis(Ethylenenitrilo)Tetracetic Acid)Hexyl Ether is a specialized bifunctional chelating agent that combines a cholesterol moiety with a powerful polyaminocarboxylate metal chelator. This molecular architecture is critical for creating targeted diagnostic and therapeutic agents, particularly in advanced medical imaging and drug delivery systems. It is primarily utilized by research institutions and pharmaceutical developers working on liposomal formulations, radiopharmaceuticals, and targeted contrast agents.

Application

• Liposome Functionalization: Key reagent for conjugating metal chelators to liposomal surfaces for targeted drug delivery and imaging.
• Radiopharmaceutical Precursor: Serves as a bifunctional chelator for labeling liposomes or other cholesterol-anchored carriers with diagnostic (e.g., 99mTc, 111In) or therapeutic (e.g., 177Lu, 90Y) radioisotopes.
• Magnetic Resonance Imaging (MRI) Contrast Agents: Used in the development of targeted MRI contrast agents by chelating gadolinium (Gd3+) or other paramagnetic ions to lipid-based nanoparticles.
• Fluorescent Probe Synthesis: Acts as a building block for creating cholesterol-anchored fluorescent sensors for membrane biology studies.
• Research & Development: Essential tool in academic and industrial R&D for studying membrane dynamics, cell targeting, and nanoparticle biodistribution.
• Therapeutic Agent Conjugation: Facilitates the attachment of therapeutic payloads to lipid carriers for site-specific treatment in oncology and other diseases.

Basic Information

Product Name	3-Cholesteryl 6-(n-Iminobis(Ethylenenitrilo)Tetracetic Acid)Hexyl Ether
CAS No.	87259-28-7
Molecular Formula	C55H93N5O10
Molecular Weight	984.37 g/mol
Synonyms	Cholesterol-DTPA-Hexyl Ether; Chol-DTPA-Hexyl Ether; 3β-Cholest-5-en-3-yl 6-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]hexyl ether; DTPA-Cholesterol Hexyl Ether; DTPA-Chol-Hexyl Ether; Bifunctional Cholesterol-DTPA Conjugate; N-(5α-Cholestan-3β-yloxy)hexyliminodiacetic Acid; Cholesterol-DTPA Chelator
EINECS	Contact for details

Quality Control

Every batch of 3-Cholesteryl 6-(n-Iminobis(Ethylenenitrilo)Tetracetic Acid)Hexyl Ether is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications tailored to meet project-specific requirements. A detailed Certificate of Analysis (COA) documenting purity (by HPLC), identity (by NMR and MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere if specified and opened in a controlled, dry environment to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.