Description

L-Proline, 5-Ethyl-, Methyl Ester, trans- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by its unique ethyl substitution at the 5-position and a trans-configuration. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, offering significant value for the development of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), peptides, and other bioactive compounds where precise structural control is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for peptide-based therapeutics and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues, potentially altering peptide conformation, stability, and biological activity.
• Asymmetric Synthesis: Acts as a precursor or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and labeled compounds for studying biological pathways and protein interactions.
• Agrochemical Development: Utilized as an intermediate in the synthesis of advanced, chiral agrochemicals such as herbicides and fungicides.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for creating libraries of novel chemical entities for screening.

Basic Information

Product Name	L-Proline, 5-Ethyl-, Methyl Ester, trans- (9Ci)
CAS No.	87251-09-0
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	trans-5-Ethyl-L-proline methyl ester; Methyl (2S,5R)-5-ethylpyrrolidine-2-carboxylate; (2S,5R)-5-Ethylpyrrolidine-2-carboxylic acid methyl ester; L-Proline, 5-ethyl-, methyl ester, trans-; 5-Ethyl-L-proline methyl ester; (S,R)-5-Ethylproline methyl ester; Proline derivative 87251-09-0
EINECS	Contact for details

Quality Control

Our L-Proline, 5-Ethyl-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.