Description

2-Pentyn-1-ol, 5-(1,3-dioxolan-2-yl)- is a specialized acetylenic alcohol derivative featuring a protected carbonyl group, making it a versatile building block in synthetic organic chemistry. This compound matters for its role as a key chiral intermediate, enabling the synthesis of complex molecules with high stereochemical control. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the asymmetric synthesis of therapeutic agents, particularly for antiviral and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the acetylenic moiety and protected aldehyde functionality are essential for biological activity.
• Ligand and Catalyst Development: Acts as a precursor for novel chiral ligands and organocatalysts used in asymmetric hydrogenation and carbon-carbon bond-forming reactions.
• Fine Chemical Manufacturing: Employed in the multistep synthesis of fragrances, flavors, and other high-value specialty chemicals requiring precise molecular architecture.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic synthesis, particularly in reactions involving alkynes and acetal-protected aldehydes.

Basic Information

Product Name	2-Pentyn-1-ol, 5-(1,3-dioxolan-2-yl)-
CAS No.	87226-66-2
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-pentyn-1-ol; 2-Pentyn-1-ol, 5-(2,2-dimethyl-1,3-dioxolan-4-yl)- (related); 5-(1,3-Dioxolan-2-yl)pent-2-yn-1-ol; Acetylenic alcohol acetal; Protected 5-oxo-2-pentyn-1-ol; 2-(2-Propynyloxy)tetrahydrofuran (isomer); Chiral alkyne diol precursor; 87226-66-2
EINECS	Contact for details

Quality Control

Our 2-Pentyn-1-ol, 5-(1,3-dioxolan-2-yl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be kept under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.