Description

(S)-Propranolol β-D-Glucuronide Sodium Salt is a high-purity, conjugated metabolite of the β-blocker (S)-propranolol. This compound is of critical importance as a certified reference standard for analytical and bioanalytical applications, ensuring accurate quantification and method validation. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in pharmacokinetic studies, drug metabolism research, and forensic toxicology.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments and validation of bioanalytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the glucuronidation pathway of (S)-propranolol, a key phase II metabolic reaction.
• Clinical and Forensic Toxicology: Used as a precise calibrant for the detection and quantification of propranolol and its metabolites in biological matrices like plasma and urine.
• Biomarker Research: Serves as a definitive standard in research investigating drug exposure and metabolic phenotypes.
• Quality Control in Manufacturing: Employed in the QC laboratories of API manufacturers to monitor for specific metabolite impurities.
• Academic Research: Utilized in university and institutional labs for studies on enantioselective metabolism, enzyme kinetics, and transporter interactions.

Basic Information

Product Name	(S)-Propranolol β-D-Glucuronide Sodium Salt
CAS No.	87144-73-8
Molecular Formula	C22H34NNaO8
Molecular Weight	463.50 g/mol
Synonyms	(S)-Propranolol Glucuronide Sodium Salt; (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol β-D-Glucopyranosiduronic Acid Sodium Salt; Sodium (2S)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol β-D-glucopyranosiduronate; Propranolol β-D-Glucuronide (S-enantiomer) Sodium Salt; (S)-Propranolol O-β-D-Glucuronide Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of (S)-Propranolol β-D-Glucuronide Sodium Salt is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and assay testing to ensure compliance with the high standards required for reference materials. A comprehensive Certificate of Analysis (COA), detailing batch-specific results from HPLC, NMR, and MS analyses, is provided with each shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Assay (HPLC)	95.0% - 105.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.