Description

Substance P, Aminoethyl(2)-Met(11)- CAS NO 87081-44-5 is a synthetic, modified peptide analog of the endogenous neuropeptide Substance P, designed for enhanced stability and specific receptor interaction. This high-purity compound is critical for advanced research in neurobiology, pharmacology, and drug discovery, where precise molecular tools are required. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focusing on neurological disorders, pain pathways, and inflammatory responses.

Application

• Neuroscience Research: As a key tool for studying the role of Substance P and its receptors (NK1) in pain signaling, neurogenic inflammation, and central nervous system function.
• Pharmacological Assay Development: Used as a reference standard or active agent in high-throughput screening (HTS) and binding assays to identify and characterize novel NK1 receptor antagonists.
• Drug Discovery & Preclinical Studies: Employed in in vitro and in vivo models to investigate therapeutic interventions for migraine, depression, nausea, and inflammatory conditions.
• Biochemical Reagent: Serves as a substrate or ligand in enzymatic studies, receptor isolation, and signal transduction pathway analysis.
• Academic & Institutional Research: Supports fundamental research into peptide structure-activity relationships (SAR) and the design of metabolically stable peptide analogs.

Basic Information

Product Name	Substance P, Aminoethyl(2)-Met(11)-
CAS No.	87081-44-5
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.6 g/mol
Synonyms	[pGlu5, MePhe8, Sar9]-Substance P (5-11); (Sar9, Met(O2)11)-Substance P; Substance P (5-11), [pGlu5, N-Me-Phe8, Sar9]-; Aminoethyl-Substance P analog; NK1 Receptor Agonist Analog; SP (5-11) analog; Modified Substance P fragment
EINECS	Contact for details

Quality Control

Our Substance P, Aminoethyl(2)-Met(11)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.