Description

(+/-)-4Hydroxy Propranolol Sulfate CAS NO 87075-33-0 is a key chemical intermediate and metabolite of the widely used β-blocker, propranolol. Its significance lies in its critical role for pharmaceutical research and development, particularly in metabolism studies, analytical method development, and the synthesis of reference standards. This compound is essential for organizations in the pharmaceutical, biotechnology, and contract research sectors focused on cardiovascular drug development and safety assessment.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of propranolol and its metabolites in biological matrices.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of propranolol.
• Analytical Method Development: Serves as a primary standard for calibrating HPLC, LC-MS, and GC-MS systems in bioanalytical laboratories.
• Impurity Profiling: Employed in the identification and quantification of related substances and degradation products in propranolol active pharmaceutical ingredient (API) and finished dosage forms.
• Chemical Synthesis Intermediate: Utilized in the research-scale synthesis of novel propranolol analogs or labeled derivatives for tracer studies.
• Toxicology & Safety Assessment: Applied in studies to understand the safety profile and potential side-effects associated with propranolol metabolism.

Basic Information

Item	Details
Product Name	(+/-)-4Hydroxy Propranolol Sulfate
CAS No.	87075-33-0
Molecular Formula	C₁₆H₂₃NO₅S
Molecular Weight	341.42 g/mol
Synonyms	4-Hydroxypropranolol Sulfate; 1-(Isopropylamino)-3-(4-hydroxy-1-naphthyloxy)-2-propanol Sulfate; Propranolol Metabolite Sulfate; 4'-Hydroxypropranolol Sulfate; (±)-4-Hydroxypropranolol Sulfate; 4-OH-Propranolol Sulfate; 1-(4-Hydroxy-1-naphthyloxy)-3-(isopropylamino)-2-propanol Sulfate
EINECS	Contact for details

Quality Control

Our (+/-)-4Hydroxy Propranolol Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identification by spectroscopic methods (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.