Description

n-L-Alanyl-L-Glutamic Acid Bis(Phenylmethyl) Ester is a protected dipeptide derivative, specifically the benzyl ester form of the alanyl-glutamate sequence. This compound is a crucial synthetic intermediate, offering a strategic combination of amino acid side-chain protection and peptide backbone for advanced chemical synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics, prodrugs, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Prodrug Development: Serves as a protected precursor in the design of ester-based prodrugs to enhance drug bioavailability and targeting.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for probing peptide-protein interactions.
• Custom Peptide Synthesis: Essential reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptide sequences for clients.
• Conjugate Chemistry: Facilitates the creation of peptide-drug conjugates (PDCs) and other bioconjugates due to its orthogonal protecting groups.

Basic Information

Product Name	n-L-Alanyl-L-Glutamic Acid Bis(Phenylmethyl) Ester
CAS No.	87063-91-0
Molecular Formula	C24H28N2O6
Molecular Weight	440.49 g/mol
Synonyms	Ala-Glu(OBzl)-OBzl; L-Alanyl-L-glutamic acid α,γ-bis(benzyl ester); H-Ala-Glu(OBzl)-OBzl; Benzyl L-alanyl-L-α-glutamate γ-benzyl ester; N-(Benzyloxycarbonyl)-L-alanyl-L-glutamic acid dibenzyl ester (related protected form); ALA-GLU(OBZL)2; (S)-2-((S)-2-Amino-3-(benzyloxy)-3-oxopropyl)pentanedioic acid 1,5-dibenzyl ester; Protected Alanylglutamate
EINECS	Contact for details

Quality Control

Our n-L-Alanyl-L-Glutamic Acid Bis(Phenylmethyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L,L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.