Description

Substance P (4-11), Pro(4)-Trp(7,9)-LeuNH2(11)- is a specific, biologically active fragment of the neuropeptide Substance P. This synthetic peptide analog is crucial for research into neurokinin-1 (NK1) receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in neuroscience, pharmacology, and pain management studies to investigate receptor specificity and develop novel therapeutic agents.

Application

• Neuroscience Research: A key tool for studying the role of Substance P in pain transmission, neuroinflammation, and central nervous system disorders.
• Pharmacological Studies: Used in receptor binding assays and functional studies to characterize NK1 receptor activity and antagonism.
• Drug Discovery & Development: Serves as a reference standard and intermediate in the development of novel analgesics and neurokinin receptor-targeted therapeutics.
• Biochemical Analysis: Employed in enzymatic stability studies and metabolic pathway analysis related to neuropeptide processing.
• Cell Signaling Research: Investigates intracellular signaling cascades activated by neurokinin receptors in various cell models.

Basic Information

Product Name	Substance P (4-11), Pro(4)-Trp(7,9)-LeuNH2(11)-
CAS No.	87026-40-2
Molecular Formula	C53H74N14O9
Molecular Weight	1043.2 g/mol
Synonyms	Substance P Fragment 4-11; [pGlu4,Trp7,9,Leu11]Substance P (4-11); SP (4-11) analog; Neurokinin receptor ligand; Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2 (modified); pGlu-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2; [pGlu4,Trp7,9,Leu11]-SP(4-11)
EINECS	Contact for details

Quality Control

Our Substance P (4-11) analog is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.