Description

Hydroxy Urea, [14C] is a carbon-14 radiolabeled analog of the well-known pharmaceutical agent hydroxyurea. This compound is specifically designed for advanced metabolic and pharmacokinetic research, providing a critical tool for tracing the fate of the parent drug in biological systems. It is an essential material for scientists in pharmaceutical R&D, contract research organizations (CROs), and academic institutions conducting studies on drug metabolism, absorption, distribution, and excretion (ADME).

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of hydroxyurea in preclinical models.
• Metabolic Pathway Elucidation: Essential for identifying and quantifying metabolites of hydroxyurea, helping to understand its biotransformation pathways.
• Bioanalytical Method Development: Serves as a critical internal standard or reference material in the development and validation of sensitive LC-MS/MS or radio-HPLC methods.
• Autoradiography Studies: Enables whole-body autoradiography (QWBA) or micro-autoradiography to visualize the tissue distribution of the drug candidate.
• Mass Balance Studies: Facilitates precise quantification of total radioactive material recovery in excreta to establish a complete mass balance.
• Environmental Fate Studies: Applied in specialized research to track the environmental degradation and persistence of the compound.

Basic Information

Product Name	Hydroxy Urea, [14C]
CAS No.	87019-64-5
Molecular Formula	C14CH4N2O2
Molecular Weight	Contact for details
Synonyms	Hydroxycarbamide-[14C]; [14C]-Hydroxyurea; Carbamohydroxamic acid-[14C]; NSC-32065-[14C]; Litalir-[14C]; Hydrea-[14C]; Urea, Hydroxy-[14C]; 1-Hydroxyurea-[14C]
EINECS	Contact for details

Quality Control

Every batch of our Hydroxy Urea, [14C] is manufactured and handled under strict quality protocols to ensure high chemical and radiochemical purity, as well as specific activity consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chemical purity, radiochemical purity, specific activity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold chain conditions (e.g., -20°C or as specified on the label) to maintain stability. Store in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR / NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent (if supplied as solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.