Description

3,5-Difluoro-4-Formylbenzeneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a formyl group and a boronic acid moiety on a difluorinated benzene ring, makes it an exceptionally versatile reagent for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for more elaborate functionalized intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the difluoro and formyl groups tune electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Utilized in the design of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronic acid handle.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3,5-Difluoro-4-Formylbenzeneboronic Acid
CAS No.	87018-11-9
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(3,5-Difluoro-4-formylphenyl)boronic acid; 4-Borono-2,6-difluorobenzaldehyde; 2,6-Difluoro-4-formylphenylboronic acid; 3,5-Difluoro-4-formylphenylboronic acid; 3,5-Difluoro-4-carboxybenzaldehyde boronic acid (deprecated); DFBA (common abbreviation); 87018-11-9 (CAS Index Name)
EINECS	Contact for details

Quality Control

Every batch of 3,5-Difluoro-4-Formylbenzeneboronic Acid is manufactured and tested under a strict quality management system. We guarantee high purity and consistency, with specifications tailored to meet the rigorous demands of research and cGMP (current Good Manufacturing Practice) environments for non-GMP use. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity (by IR and NMR), and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.