Description

β-Nerve Growth Factor, Human CAS NO 86923-98-0 is a critical neurotrophic protein essential for the survival, development, and function of neurons. This highly purified recombinant human protein is vital for advanced neuroscience research and therapeutic development. It is primarily used by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurodegenerative diseases, nerve regeneration, and cell culture applications.

Application

• Neuroscience Research: Fundamental studies on neuronal differentiation, survival, and axonal growth in primary neuronal cultures.
• Drug Discovery & Screening: Used in high-throughput assays to identify novel compounds for treating neurodegenerative conditions like Alzheimer's and Parkinson's disease.
• Cell Culture & Differentiation: Essential component in media for the maintenance and directed differentiation of neural stem cells and PC12 cells.
• Therapeutic Development: Investigational agent in pre-clinical studies for nerve injury repair, peripheral neuropathies, and spinal cord regeneration.
• Biomarker & Diagnostic Research: Utilized in developing assays to measure NGF levels in biological samples for diagnostic purposes.
• Toxicity & Safety Pharmacology: Employed in neurotoxicity studies to assess the protective effects of candidate drugs on neuronal health.

Basic Information

Product Name	β-Nerve Growth Factor, Human
CAS No.	86923-98-0
Molecular Formula	C990H1528N262O300S10
Molecular Weight	Approx. 26.5 kDa
Synonyms	Human β-NGF; Recombinant Human Nerve Growth Factor; NGF-β; β-NGF; Nerve Growth Factor, Beta Polypeptide; rhNGF; NGFB; HSAN5; Neurotrophin; MGC161426
EINECS	Contact for details

Quality Control

Our recombinant β-Nerve Growth Factor, Human is produced under stringent conditions and undergoes comprehensive analytical testing to ensure high biological activity, purity, and consistency. Quality is verified through multiple orthogonal methods including SDS-PAGE, HPLC, and bioactivity assays. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, sterility, and specific activity. Our quality system is designed to support research and pre-clinical development requiring reliable and traceable materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98.0%
Biological Activity	ED50 ≤ 1.0 ng/mL (PC12 cell proliferation assay)
Endotoxin Level	< 1.0 EU/μg
Identification (Mass Spec)	Consistent with theoretical molecular weight
Sterility (Membrane Filtration)	Sterile
Solubility	Soluble in water or PBS (pH 7.2-7.4)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.