Description

Hemoglobin F Kennestone is a highly purified, standardized preparation of fetal hemoglobin (HbF), a key protein for oxygen transport in developing fetuses. This product is essential for research and diagnostic applications requiring a reliable and consistent source of authentic HbF. It serves as a critical reference material and reagent for scientists and manufacturers in the life sciences and in vitro diagnostics (IVD) sectors.

Application

• Clinical Diagnostics & IVD Manufacturing: Used as a primary standard or calibrator in assays for the detection and quantification of fetal hemoglobin, crucial for diagnosing hemoglobinopathies like β-thalassemia and sickle cell disease.
• Biomedical Research: Serves as a vital reagent in studies of hemoglobin switching, fetal development, and the molecular mechanisms of hereditary blood disorders.
• Hematology Reference Standards: Provides a benchmark for instrument calibration and method validation in clinical laboratories to ensure accurate HbF measurement.
• Pharmaceutical Development: Utilized in research exploring therapeutic strategies aimed at reactivating fetal hemoglobin production in patients with adult hemoglobin defects.
• Quality Control in Bioprocessing: Acts as a control material in the production and quality assurance of related diagnostic kits and biological products.

Basic Information

Product Name	Hemoglobin F Kennestone
CAS No.	86923-77-5
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Fetal Hemoglobin
Hb F
Hemoglobin F
α2γ2 Hemoglobin
Fetal Haemoglobin
Kennestone Hemoglobin F
HbF Standard
EINECS	Contact for details

Quality Control

Our Hemoglobin F Kennestone is produced and tested under stringent quality management protocols. Each lot is characterized for identity, purity, and functional activity to ensure it meets the exacting requirements for diagnostic and research use. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), spectral properties, and functional characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting and freezing at -20°C or below to maintain optimal stability.

Specification

Item	Specification
Appearance	Dark red, lyophilized powder or solution
Identification (HPLC/Electrophoresis)	Corresponds to Hemoglobin F standard
Purity (HPLC)	≥ 95% (HbF)
Absorbance Ratio (A540/A280)	Within specified range
Methemoglobin Content	< 5%
Solubility	Clear solution in appropriate buffer
Biological Activity (O2 Binding)	Functional

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.