Description

(Rs)-4,4,4-Trifluoro-3-Hydroxybutyric Acid CAS NO 86884-21-1 is a high-value chiral fluorinated building block essential for advanced organic synthesis. This compound is critical for introducing the trifluoromethyl-hydroxybutyrate moiety, a key structural motif that can significantly alter the physicochemical and metabolic properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in metabolic disease and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties.
• Biochemical Research: Acts as a substrate or inhibitor analog in enzymatic studies, leveraging its structural similarity to natural metabolites.
• Fluorine Chemistry: A versatile starting material for exploring new fluorination methodologies and creating complex fluorinated architectures.

Basic Information

Product Name	(Rs)-4,4,4-Trifluoro-3-Hydroxybutyric Acid
CAS No.	86884-21-1
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	(R,S)-4,4,4-Trifluoro-3-hydroxybutanoic Acid; (±)-4,4,4-Trifluoro-3-hydroxybutyric Acid; DL-4,4,4-Trifluoro-3-hydroxybutyric Acid; 3-Hydroxy-4,4,4-trifluorobutanoic Acid; 4,4,4-Trifluoro-3-hydroxybutanoic Acid; rac-4,4,4-Trifluoro-3-hydroxybutyric Acid; TFHBA
EINECS	Contact for details

Quality Control

Our (Rs)-4,4,4-Trifluoro-3-Hydroxybutyric Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the exacting standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential degradation. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (Rs)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.