Description

2-(Difluoromethoxy)Phenylacetic Acid is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethoxy group attached to a phenylacetic acid core, makes it a critical intermediate for developing novel compounds with enhanced biological activity and physicochemical properties. This high-purity intermediate is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting inflammation, metabolic disorders, and central nervous system (CNS) diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies, where its structure influences dielectric anisotropy and viscosity.
• Advanced Material Research: Employed in polymer chemistry and material science to incorporate fluorine into aromatic polymers, enhancing their thermal stability, chemical resistance, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide formations to introduce the 2-(difluoromethoxy)phenyl moiety into more complex molecular architectures.

Basic Information

Product Name	2-(Difluoromethoxy)Phenylacetic Acid
CAS No.	86867-68-7
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(Difluoromethoxy)benzeneacetic acid; α-(Difluoromethoxy)phenylacetic acid; (2-(Difluoromethoxy)phenyl)acetic acid; Benzeneacetic acid, 2-(difluoromethoxy)-; o-(Difluoromethoxy)phenylacetic acid; DFMPA; 86867-68-7
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Phenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.