Description

3,3-Difluoro-Cyclobutanecarbonitrile is a high-value, versatile fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring a strained cyclobutane ring and a nitrile group, makes it a critical intermediate for introducing the difluorocyclobutyl moiety into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It enables the exploration of novel chemical space in drug discovery programs, particularly for creating bioactive compounds with enhanced metabolic stability and membrane permeability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry for probing structure-activity relationships (SAR).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluorocyclobutyl group can influence biological activity and environmental fate.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Potential monomer or additive for developing advanced polymers with specific thermal or chemical resistance properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the properties of fluorinated alicyclic compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	3,3-Difluoro-Cyclobutanecarbonitrile
CAS No.	86770-80-1
Molecular Formula	C5H5F2N
Molecular Weight	117.10 g/mol
Synonyms	3,3-Difluorocyclobutanecarbonitrile; 3,3-Difluorocyclobutanenitrile; Cyclobutanecarbonitrile, 3,3-difluoro-; 3,3-Difluoro-1-cyanocyclobutane; 1-Cyano-3,3-difluorocyclobutane
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-Cyclobutanecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.