Description

1,23,25-Trihydroxyvitamin D3 is a biologically active metabolite of vitamin D3, playing a crucial role in calcium and phosphate homeostasis. This high-purity compound is essential for advanced research and development in endocrinology and metabolic bone disease studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-grade reference standards for analytical and clinical applications.

Application

• Pharmaceutical Research & Development for novel vitamin D analogs and therapies.
• Biochemical Research as a critical reference standard in metabolic pathway studies.
• Clinical Research for investigating the role of vitamin D metabolites in bone health and disease.
• Manufacturing of high-purity analytical standards for HPLC, LC-MS, and other instrumental methods.
• Development of in-vitro diagnostic (IVD) assays and calibration materials.
• Cell culture and molecular biology studies involving vitamin D receptor (VDR) signaling.

Basic Information

Product Name	1,23,25-Trihydroxyvitamin D3
CAS No.	86701-33-9
Molecular Formula	C₂₇H₄₄O₅
Molecular Weight	448.64 g/mol
Synonyms	1,23,25-Trihydroxycholecalciferol; 1α,23,25-Trihydroxyvitamin D3; 1α,23,25-Trihydroxycholecalciferol; 1α,23,25-Trihydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-ol; 23,25-Dihydroxy-1α-hydroxyvitamin D3; 1α,23,25-Trihydroxy-9,10-secocholesta-5,7,10(19)-trien-3-ol; (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,23,25-tetrol
EINECS	Contact for details

Quality Control

Our 1,23,25-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.