Description

S-Adenosyl-L-Methionine p-Toluenesulfonate Salt is a stabilized, pharmaceutically relevant salt form of the critical biological cofactor S-adenosylmethionine (SAMe). This compound is essential for its role in key biochemical processes, including methylation, transsulfuration, and aminopropylation. It is primarily utilized in the research and development of pharmaceuticals and nutraceuticals, particularly for applications in liver health, neurological function, and mood support.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Core component in prescription and over-the-counter formulations targeting liver disorders, osteoarthritis, and depressive symptoms.
• Nutraceutical and Dietary Supplement Production: A key ingredient in high-purity supplements for supporting joint health, liver detoxification, and emotional well-being.
• Biochemical and Life Science Research: Used as a critical methyl group donor in enzymatic studies, epigenetics research, and metabolic pathway analysis.
• Reference Standard and Analytical Testing: Serves as a certified reference material (CRM) for quality control and assay development in pharmaceutical laboratories.
• Cell Culture and Microbiology: Employed in specialized media and growth conditions for studying cellular metabolism and gene expression.
• Precursor for Advanced Intermediates: Used in the synthesis of more complex biochemical compounds and labeled analogs for tracer studies.

Basic Information

Product Name	S-Adenosyl-L-Methionine p-Toluenesulfonate Salt
CAS No.	86562-85-8
Molecular Formula	C15H22N6O5S • C7H8O3S
Molecular Weight	534.57 g/mol
Synonyms	S-Adenosylmethionine Tosylate; SAMe Tosylate; AdoMet Tosylate; SAM Tosylate; S-Adenosyl-L-Methionine p-Toluenesulfonate; (3S)-5'-[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine p-toluenesulfonate; 86562-85-8; SAMe tosylate salt
EINECS	Contact for details

Quality Control

Our S-Adenosyl-L-Methionine p-Toluenesulfonate Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical and nutraceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized. For short-term use, store desiccated at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Specific Rotation	+47° to +52° (c=1 in 0.1N HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.