Description

Mu-Conotoxin GIIIA is a highly selective and potent peptide neurotoxin originally isolated from the venom of the marine cone snail *Conus geographus*. This compound is of significant value in neuroscience research as a specific and irreversible blocker of voltage-gated sodium channels, particularly the skeletal muscle subtype (NaV1.4). It is an essential tool for researchers and pharmaceutical developers studying ion channel function, neuromuscular disorders, and pain pathways.

Application

• Neuroscience Research: A critical pharmacological tool for studying the structure, function, and kinetics of voltage-gated sodium channels (NaV1.4) in skeletal muscle.
• Drug Discovery & Development: Used in high-throughput screening assays to identify and characterize novel analgesics, anesthetics, and therapeutics targeting sodium channels.
• Physiological Studies: Employed to investigate neuromuscular transmission, muscle excitability, and the pathophysiology of channelopathies such as myotonia and periodic paralysis.
• Toxicology & Venom Research: Serves as a reference standard for understanding the mechanism of action of conotoxins and for developing antivenoms.
• Biochemical Reagent: Used in ligand-binding studies and for the affinity purification or labeling of specific sodium channel subtypes.

Basic Information

Product Name	Mu-Conotoxin GIIIA
CAS No.	86394-16-3
Molecular Formula	C97H155N37O30S7
Molecular Weight	2549.9 g/mol
Synonyms	μ-Conotoxin GIIIA; Mu-Conotoxin GIIIA; Geographutoxin II; GIIIA; μ-CTX GIIIA; Conotoxin GIIIA; Mu Conotoxin from Conus geographus; SH-bridged cyclic peptide
EINECS	Contact for details

Quality Control

Our Mu-Conotoxin GIIIA is produced and handled under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized using advanced analytical techniques, including mass spectrometry and chromatography, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and biological activity (where applicable) is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single-Chain Proportion (HPLC)	≥ 90%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.