Description

5-Hydroxy Propafenone Hydrochloride is a key pharmaceutical intermediate and metabolite of the antiarrhythmic drug propafenone. This compound matters for its critical role in drug development, metabolism studies, and the synthesis of high-purity active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, research institutions, and analytical laboratories focused on cardiovascular therapeutics and pharmacokinetic research.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Propafenone Hydrochloride and related antiarrhythmic APIs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and biological activity of propafenone.
• Impurity Standard: Serves as a known impurity standard in HPLC and LC-MS analysis to ensure the purity and safety of the final drug product.
• Research & Development: Utilized in academic and industrial R&D for exploring new derivatives and formulations in cardiovascular medicine.
• GMP Manufacturing: Supplied for use in Good Manufacturing Practice (GMP) compliant production processes for finished dosage forms.

Basic Information

Product Name	5-Hydroxy Propafenone Hydrochloride
CAS No.	86384-10-3
Molecular Formula	C21H28ClNO3
Molecular Weight	377.90 g/mol
Synonyms	5-Hydroxypropafenone HCl; 1-[2-Hydroxy-3-(propylamino)propoxy]-5-hydroxy-3-phenylpropiophenone Hydrochloride; 5-OH-Propafenone Hydrochloride; Propafenone Metabolite 5-Hydroxy Hydrochloride; N-Propyl-5-hydroxy-3-phenylpropiophenone Hydrochloride; 5-Hydroxy Propafenone HCl Salt; 5-Hydroxy-3-phenyl-1-[2-(propylamino)propoxy]propiophenone Hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Hydroxy Propafenone Hydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and purity, to ensure it meets high-grade specifications suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.