Description

Hemoglobin F Caltech is a highly purified, research-grade preparation of fetal hemoglobin, a critical protein for oxygen transport in developing fetuses. This product is essential for advancing scientific understanding of hemoglobinopathies, developmental biology, and comparative oxygen-binding kinetics. It serves as an indispensable reference standard and key reagent for researchers and quality control laboratories in the fields of hematology, biochemistry, and diagnostic assay development. Its consistent quality supports reliable and reproducible experimental outcomes in both academic and industrial R&D settings.

Application

• Biochemical Research: Used as a primary reference material in studies of hemoglobin structure, function, and allosteric regulation.
• Diagnostic Standard: Serves as a critical calibrator and control in clinical diagnostic assays designed to detect and quantify fetal hemoglobin (HbF) levels.
• Therapeutic Development: Employed in research focused on sickle cell disease and β-thalassemia, where modulating HbF expression is a key therapeutic strategy.
• Comparative Studies: Facilitates comparative analysis of oxygen affinity and stability between fetal (HbF) and adult (HbA) hemoglobin.
• Educational & Training: Used in advanced university and professional training courses for protein purification and characterization techniques.
• Biomarker Investigation: Supports research into HbF as a potential biomarker for certain hematological conditions and physiological states.

Basic Information

Product Name	Hemoglobin F Caltech
CAS No.	86290-88-2
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Fetal Hemoglobin; Hb F; Hemoglobin F; α2γ2 Hemoglobin; γ-Globin containing Hemoglobin; Alkali-resistant Hemoglobin; F Hemoglobin; Foetal Haemoglobin
EINECS	Contact for details

Quality Control

Our Hemoglobin F Caltech is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to a comprehensive suite of analytical tests, including purity assessment by HPLC, spectral analysis for characteristic Soret band absorption, and functional oxygen-binding assays. A Certificate of Analysis (COA) detailing specific results for identity, purity, and activity is provided with every shipment, supporting compliance with rigorous research and diagnostic standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR / UV-Vis)	Conforms to standard for Hemoglobin F
Purity (HPLC)	≥ 95% (HbF)
Assay (Functional)	Contact for details
Moisture Content	≤ 5.0% (for lyophilized powder)
Solubility	Clear solution in buffer or water
Endotoxin	< 1.0 EU/mg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.